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E2 circulates at 15 to 4 times the concentration of E1 in premenopausal nonpregnant women. E2 and E1 can be converted into each other and both can be inactivated via hydroxylation and conjugation.
E2 levels in men and postmenopausal women are much lower than in nonpregnant women while E1 levels differ.
. E2 demonstrates 125 to 5 times the biological potency of E1.
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