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E2 circulates at 15 to 4 times the concentration of E1 in premenopausal nonpregnant women. E2 and E1 can be converted into each other and both can be inactivated via hydroxylation and conjugation.
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E2 levels in men and postmenopausal women are much lower than in nonpregnant women while E1 levels differ.
. E2 demonstrates 125 to 5 times the biological potency of E1.
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